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Pharmaceutical composition, application thereof, sterile container and kit

A technology of aseptic containers and compositions, applied in the direction of drug combinations, medical containers, infusion sets, etc.

Active Publication Date: 2020-04-03
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the response rate of cancer patients to PD-L1 monoclonal antibody is only about 20%

Method used

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  • Pharmaceutical composition, application thereof, sterile container and kit
  • Pharmaceutical composition, application thereof, sterile container and kit
  • Pharmaceutical composition, application thereof, sterile container and kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] In order to prove that the present invention has a good curative effect, animal experiments verify the therapeutic effect of the combination of tanshinone IIA and PD-L1 on the mouse non-small cell lung cancer model as follows:

[0034] 1 material

[0035] 1.1 Cell culture

[0036]Lewis murine lung adenocarcinoma cells (LLC) were purchased from the Cell Culture Center of Chinese Academy of Medical Sciences (Cell Culture Center of Chinese Academy of Medical Sciences; CAMS; People's Republic of China, Beijing). 90% DMEM medium (Dulbecco's modified Eagle's medium, Gibco BRL, USA), 10% FBS fetal bovine serum (fetal bovine serum, Gibco BRL, USA), in 5% CO 2 , 95%O 2 cultured in a 37°C incubator with constant temperature and humidity. Replace the culture medium every 2 to 3 days or determine whether to pass passage according to the cell density.

[0037] 1.2 Experimental animals

[0038] Healthy SPF-grade female C57BL / 6 mice were used, purchased from the Institute of Labo...

Embodiment 2

[0068] 1 material

[0069] 1.1 Experimental animals

[0070] Twelve female NOD / SCID mice (6-8 weeks, 18-22g) were purchased from the Institute of Laboratory Animal Science (Institute of Laboratory Animal Science) of CAMS, Beijing, People's Republic of China, and were subjected to 12 hours of light under pathogen-free conditions. / dark cycle feeding acclimation for one week. Food and water were given throughout the experiment. Lewis cells were trypsinized and resuspended in 10% calf serum (5×10 5 cells / mL) in DMEM medium, each mouse was subcutaneously injected with 0.1 mL of Lewis cell suspension in the armpit of the left forelimb for inoculation.

[0071] 1.2 Drugs

[0072] Monomer tanshinone IIA with a purity of >98% was purchased from Shanghai Yuanye Biotechnology Co., Ltd., and was first dissolved in 1% DMSO, and then dissolved in 0.9% saline.

[0073] 2 methods

[0074] Twelve NOD / SCID mice were randomly divided into 2 groups, 6 in each group. After grouping, each g...

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Abstract

The invention relates to a pharmaceutical composition, an application thereof, a sterile container and a kit. The pharmaceutical composition comprises a therapeutically effective amount of tanshinoneII A and a therapeutically effective amount of at least one immune checkpoint inhibitor. According to the pharmaceutical composition, the anti-tumor treatment effect of the immune checkpoint inhibitoron lung cancer is improved, and meanwhile side effects are reduced.

Description

technical field [0001] The present invention generally relates to the field of medicine, in particular to a pharmaceutical composition and its application, aseptic container and kit. Background technique [0002] Cancer is one of the major diseases that seriously endanger human health. Overcoming cancer has always been a research topic attracting worldwide attention. According to the survey of the World Health Organization, cancer patients are increasing year by year. Cancer is already one of the four major killers that seriously affect human health. It is characterized by uncontrollable growth and spread of malignant cells, as well as tissue infiltration. According to the "Classification of Diseases and Causes of Death" published by the Ministry of Health, it belongs to the diseases listed as malignant tumors. Currently, in addition to surgery, chemotherapy, and radiation therapy, which are the standard treatments for cancer, cancer immunotherapy has been developed as a ne...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/58A61P35/00A61M5/178A61J1/10
CPCA61J1/10A61K31/58A61K45/06A61M5/178A61P35/00A61K2300/00
Inventor 肖伟王永华郑春丽粟星姜梦王振中
Owner JIANGSU KANION PHARMA CO LTD
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