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Applications of miR-9 in preparing medicines for treating acute coronary syndrome

A technology of mir-9, 1.mir-9, applied in the field of medicine

Active Publication Date: 2019-01-29
HAINAN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Recently, more and more researchers have recognized the role of miRNAs in cardiovascular diseases, but how these miRNAs are involved in the pathogenesis and development of cardiovascular diseases is still unclear.

Method used

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  • Applications of miR-9 in preparing medicines for treating acute coronary syndrome
  • Applications of miR-9 in preparing medicines for treating acute coronary syndrome
  • Applications of miR-9 in preparing medicines for treating acute coronary syndrome

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Embodiment Construction

[0026] Based on the above description of the content of the invention, those skilled in the art can fully apply the present invention, and all the same principles or similar modifications should be considered to be included within the scope of the present invention.

[0027] Microarray analysis: Microarray data for ACS GSE19339 were downloaded from Gene Expression Omnibus (GEO, a subdatabase of the National Center for Biotechnology Information (NCBI)). Based on the powerful multi-array averaging (RMA) algorithm, the downloaded Affy software package is used for background correction and normalization of chip data preprocessing. The limma package of R language was used to identify differentially expressed genes (DEGs) of ACS. Calculate the log2 fold change (log2FC) of the gene. After correction, p-values ​​are expressed as adj.P.Val. |log2FC|>2.0 and adj.P.Val<0.01 were considered to be significantly differentially expressed, and genes related to ACS were searched in the DisGe...

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Abstract

The invention belongs to the technical field of medicines, and relates to applications of miR-9 in preparing medicines for treating acute coronary syndrome. MiR-9 can serve as a biomarker for patientssuffering from acute coronary syndrome and plays an important role in atherosclerotic plaque and blood vessel remodeling of the acute coronary syndrome, wherein the basic mechanism of the p38MAPK channel is related. MiR-9 can serve as a potential treatment target for the acute coronary syndrome.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to the use of miR-9 in preparing medicine. Background technique [0002] Acute coronary syndrome (ACS), including unstable angina and myocardial infarction, is a key contributor to premature death, morbidity, and hospitalization. The main clinical manifestations of ACS are chest pain and coronary artery occlusion, resulting in reduced cardiac blood flow and myocardial damage. Rupture or invasion of atherosclerotic plaques is considered a common pathophysiology of ACS, and ACS patients also have more active inflammation. Early diagnosis of ACS can be based on imaging modalities (echocardiography, MRI, and CT) and biomarkers (highly sensitive or ultrasensitive cardiac troponin assays) prior to targeted therapy. In the treatment, recurrence and early prevention of ACS, active antiplatelet, antithrombotic, antiischemic and lipid-lowering agents combined with lifestyle intervention, chan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/713A61K45/00A61P9/10
CPCA61K31/713A61K45/00A61P9/10
Inventor 刘启兵虞道锐王涛黄静方星悦樊好飞易国辉刘嫱曾祥周
Owner HAINAN MEDICAL COLLEGE
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