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Anthraquinone compound from fungi in deep sea and application of anthraquinone compound in preparation of antiallergic drugs

A compound and anthraquinone technology are applied to anthraquinone compounds and their application fields in the preparation of antiallergic drugs, which can solve the problems of limited types of allergens, achieve good application prospects and promote effective application.

Active Publication Date: 2018-12-25
THIRD INST OF OCEANOGRAPHY MINIST OF NATURAL RESOURCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the types of allergens that can be clearly identified in medicine are currently limited, and allergic reactions to unknown allergens are still hard to prevent.

Method used

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  • Anthraquinone compound from fungi in deep sea and application of anthraquinone compound in preparation of antiallergic drugs
  • Anthraquinone compound from fungi in deep sea and application of anthraquinone compound in preparation of antiallergic drugs
  • Anthraquinone compound from fungi in deep sea and application of anthraquinone compound in preparation of antiallergic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: Preparation of anthraquinone compounds

[0024] (1) Aspergillus nidulans (can be purchased from the China Marine Microorganism Culture Collection Management Center, preservation number: MCCC 3A00050) was added to 40 1L Erlenmeyer flasks containing 80g oats, and cultured at 25°C for 40 day, add ethyl acetate to extract, degrease through petroleum ether and dichloromethane, and concentrate under low pressure to obtain 100g of fermented crude extract;

[0025] (2) The crude extract fermented in step (1) is subjected to silica gel column (49 × 460mm) separation, adopts dichloromethane-methanol solution gradient elution (CH 2 Cl 2 -MeOH, 100:0→0:100) into 7 fractions (Fr.1–Fr.7);

[0026] (3) the fifth fraction Fr.5(CH in step (2) 2 Cl 2 -MeOH, obtained by eluting at 20:80) for ODS chromatographic column (26×310mm) separation, using methanol-water solution for gradient elution (MeOH-H 2 O, 5:95→100:0), divided into 6 sub-fractions (Fr.5.1–Fr.5.6);

[0027...

Embodiment 2 Embodiment 1

[0032] The in vitro antiallergic activity test of the compound prepared in embodiment 2 embodiment 1

[0033] Mast cells have not yet obtained a good cell line and cannot be subcultured in vitro, so it is difficult to obtain a large number of cells with uniform characteristics for experimental research. The RBL-2H3 cell line has a similar cell structure and degranulation reaction mechanism to mast cells. More importantly, this cell line can be stably subcultured in vitro, so it is often used as a surrogate model of mast cells to study the function of mast cells. Further application in allergic disease research.

[0034] In this example, the IgE-mediated RBL-2H3 cell model was selected to detect the degranulation efficiency of the cells after sensitization, calculate the inhibition rate of the compound on the degranulation efficiency of the cells, and further calculate the anti-allergic activity of the compound.

[0035] The present embodiment is divided into following 4 group...

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Abstract

The invention discloses an anthraquinone compound from fungi in deep sea and application of the anthraquinone compound in preparation of antiallergic drugs. The structure of the anthraquinone compoundfrom fungi in deep sea is shown in formula (I), and the anthraquinone compound can be used for preparing the antiallergic drugs.

Description

technical field [0001] The invention belongs to the application field of marine microbial drugs, and more specifically, the invention relates to an anthraquinone compound and its application in preparing antiallergic drugs. Background technique [0002] Allergy refers to a reproducible adverse reaction that can affect different organs of the body caused by the immune system's specific immune response to the allergen after a specific substance (such as food, drug, etc.) enters the human body, which can cause urticaria, nasal congestion, and nasal congestion. Itching, wheezing, nausea and vomiting, tachycardia and other multi-system reactions. These reactions can range from mild local reactions to severe, life-threatening reactions. [0003] Allergy is a global health problem affecting millions. The results of epidemiological studies show that the prevalence of allergies has been increasing in the past 20 years, and the current recommended allergy treatment is still based on...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/04A61K31/343A61P37/08C12P17/18C12R1/66
CPCA61P37/08C07D493/04C12P17/181
Inventor 杨献文邢翠平夏金梅
Owner THIRD INST OF OCEANOGRAPHY MINIST OF NATURAL RESOURCES
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