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New application of CD133 plasmid

A plasmid-based technology, applied in cells modified by introducing foreign genetic material, applications, recombinant DNA technology, etc., can solve the problems of breast cancer recurrence and metastasis

Inactive Publication Date: 2016-05-25
天津市第四中心医院
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] The existence of CSC is one of the most important factors affecting the treatment effect and prognosis of breast cancer. The current clinical radiotherapy and chemotherapy can only eliminate common breast cancer cells, while the remaining BCSCs that are resistant to radiotherapy and chemotherapy can continue to proliferate, leading to breast cancer. Recurrence and metastasis, so finding an effective way to kill CSC has become a new direction for breast cancer treatment

Method used

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Embodiment 1

[0019] 1. Preparation of whole cell lysate of breast cancer MCF-7 cell stem cells

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Abstract

The invention provides new application of CD133 plasmid. The CD133 plasmid can be effectively used for enhancing the in-vitro killing effect of DC-CIK on breast cancer stem cells.

Description

technical field [0001] The present invention relates to a new application of CD133 plasmid. Background technique [0002] Breast cancer is the most common malignancy in women worldwide. A large number of evidences show that it is precisely because of the existence of breast cancer stem cells (Breast Cancer Stem Cell, BCSC) that it is easy to transfer, relapse and resist chemotherapy and radiotherapy. Adoptive cell immunotherapy (ACI), which has emerged in recent years, is a new therapy for tumors that are not sensitive to radiotherapy and chemotherapy. It has broad clinical prospects and has received more and more attention. [0003] The existence of CSC is one of the most important factors affecting the treatment effect and prognosis of breast cancer. The current clinical radiotherapy and chemotherapy can only eliminate common breast cancer cells, while the remaining BCSCs that are resistant to radiotherapy and chemotherapy can still proliferate continuously, leading to br...

Claims

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Application Information

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IPC IPC(8): C12N5/10C12N5/0783C12N15/867
CPCC12N5/0636C12N5/0639C12N15/86C12N2740/15043
Inventor 孙雯雯
Owner 天津市第四中心医院
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