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Polyaniline-base injectable photo-thermal hydrogel

A technology based on polyaniline and hydrogel, applied in the direction of wave energy or particle radiation treatment materials, organic active ingredients, non-effective ingredients of polymer compounds, etc., to achieve the effect of simple preparation method, easy control, and mild reaction conditions

Inactive Publication Date: 2016-04-06
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports of preparing it into photothermal gel preparations.
However, there are no research reports on the use of cyclodextrose precision polyrotaxane hydrogels for photothermal therapy.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0026] (1) Preparation of poly-N-phenylglycine:

[0027] The monomer N-phenylglycine (0.30g, 2mmol) and the oxidant ammonium persulfate (0.46g, 2mmol) were dissolved in 0.1M H 2 SO 4 In an ice bath, keep the temperature at 0-5°C, add the oxidant ammonium persulfate solution dropwise to the monomer solution, and the dropwise addition time is 2h. After the dropwise addition was completed, the reaction was continued in an ice bath for 5 h, and then raised to room temperature for 24 h. Stop responding. Filter and wash three times with distilled water. After vacuum drying at 50°C for 48 hours, a dark green solid was obtained, namely poly-N-phenylglycine (PPG).

[0028] (2) Preparation of polyethylene glycol grafted poly-N-phenylglycine:

[0029] Dissolve PPG (0.010 g, 0.065 mmol of repeating unit PG) in 5 ml of DMSO, add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (0.025 g, 0.13 mmol) and N-hydroxy Sulfosuccinimide (0.015g, 0.13mmol), stirred and activated for 2h, then adde...

preparation Embodiment 2

[0033] The difference from the above-mentioned Preparation Example 1 is that during the preparation of (1) poly-N-phenylglycine, 0.1M H 2 SO 4 Change to 1M aqueous HCl. As a result, poly-N-phenylglycine was also successfully prepared, and it was finally proved that the quasi-polyrotaxane supramolecular photothermogel based on the composite of cyclodextrin and PPG-g-PEG graft in the present invention was also formed.

[0034] Test Example

[0035] The experimental method is as follows:

[0036] The PPG-g-PEG graft obtained in (2) in Preparation Example 1 is formulated into an aqueous solution of 28mg / ml, irradiated with an 808nm laser (1-2W, spot diameter 5mm), and records the temperature of the solution with an infrared thermal imager Variations with lighting time.

[0037] With 808nm laser (1-2W, light spot diameter 5mm) irradiation with the obtained polyaniline-based photothermothermal gel of step (3) in the preparation embodiment 1, the temperature of gel is recorded wi...

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Abstract

The invention discloses polyaniline-base injectable photo-thermal hydrogel which is binary-system hydrogel composed of alpha-cyclodextrin and a water-soluble high-polymer photo-thermal material. The water-soluble high-polymer photo-thermal material is polyethylene glycol grafted poly-N-phenylglycine comprising a main chain and a side chain, and the main chain is poly-N-phenylglycine (PPG) while the side chain is polyethylene glycol (PEG). The hydrogel has good photothermal conversion capability and can be used for photothermal therapy, meanwhile, the hydrogel can load chemotherapy drugs, photodynamic reagents and fluorescence imaging reagents to respectively obtain a photo-thermal hydrogel carry system which has chemotherapy, photodynamic therapy and imaging functions and is a biocompatible multifunctional photo-thermal response-type carrier hydrogel system, and the hydrogel has broad application prospect in drug carriers, photocontrol drug release, photothermal therapy, photodynamic therapy, tissue engineering and the like.

Description

technical field [0001] The invention relates to photothermal therapy reagents and belongs to the technical field of biomedical materials. It specifically relates to polyaniline-based injectable photothermal gel, and also relates to its preparation method and application. Background technique [0002] Photothermal therapy is a method that uses materials with photothermal conversion function to absorb near-infrared light under laser irradiation, converts light energy into heat energy, and generates high heat, thereby killing diseased cells to achieve a therapeutic effect. It has the characteristics of precision, high efficiency, controllability, non-invasiveness, and low side effects. At present, photothermal therapy usually prepares photothermal materials into targeted nanoparticles or hydrogel formulations for treatment. Compared with targeted nanoparticles, photothermal hydrogel formulations can achieve in-situ fixed-point therapy and repeatable therapy, which is very eff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/06A61K31/704A61K47/40A61K47/34A61K49/00
CPCA61K41/0052A61K9/06A61K31/704A61K41/0071A61K47/34A61K47/40A61K49/0041A61K49/0054A61K49/0073
Inventor 沈星灿刘婵娟蒋邦平胡海露
Owner GUANGXI NORMAL UNIV
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