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Sugar alcohol hydrophilic interaction chromatography stationary phase, synthesis and applications thereof

A chromatographic stationary phase and hydrophilic interaction technology, applied in the field of sugar alcohol hydrophilic interaction chromatographic stationary phase and its synthesis and application

Inactive Publication Date: 2015-06-17
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Abstract
  • Description
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Problems solved by technology

However, due to the complexity of actual samples and the diversity of separation requirements, there is no hydrophilic interaction chromatography that can meet the separation requirements of most polar compounds. Therefore, it is very important to develop a new hydrophilic interaction chromatography stationary phase. Work

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  • Sugar alcohol hydrophilic interaction chromatography stationary phase, synthesis and applications thereof
  • Sugar alcohol hydrophilic interaction chromatography stationary phase, synthesis and applications thereof
  • Sugar alcohol hydrophilic interaction chromatography stationary phase, synthesis and applications thereof

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Embodiment Construction

[0020] The present invention also relates to the preparation method of above-mentioned chromatographic stationary phase, and synthetic route is as follows Figure 6 Shown:

[0021] In the schematic diagram of the synthesis route of the sugar alcohol hydrophilic interaction chromatography stationary phase, ROH represents xylitol or maltitol.

[0022] The specific operation steps are as follows:

[0023] (1) Dissolve 5.0g of xylitol or maltitol in 100ml of anhydrous pyridine, and drop 6.8g or 3.0g of silane reagent (EtO) into the above solution through a dropping funnel at 80°C 3 SiCH 2 CH 2 CH 2 NCO, continue to react for 6h after the dropwise addition;

[0024] (2) Add 6.0 g of dry silica gel to the solution obtained from the reaction in (1), and reflux for 24 hours;

[0025] (3) After cooling, filter, and wash the solid product successively with pyridine, ethanol, water, ethanol and acetone, and then vacuum-dry at 60°C to obtain the target stationary phase.

[0026] Th...

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Abstract

The present invention relates to synthesis of a sugar alcohol hydrophilic interaction chromatography stationary phase, and applications of the sugar alcohol hydrophilic interaction chromatography stationary phase in hydrophilic interaction chromatography. According to the present invention, xylitol or maltitol is adopted as a starting material, and a two-step reaction is performed to quickly and easily synthesize the target hydrophilic interaction chromatography stationary phase; and with application of the novel hydrophilic interaction chromatography stationary phase in the hydrophilic interaction chromatography, the good separation characteristic is provided in the separation of the polar organic compound and the water-soluble organic compound.

Description

technical field [0001] The invention relates to the design of the sugar alcohol hydrophilic interaction chromatography stationary phase, the invention also relates to the preparation method of the above stationary phase, and the application of the above stationary phase in the hydrophilic interaction chromatography. technical background [0002] In the traditional liquid chromatography separation mode, reversed-phase chromatography using C8 / C18 stationary phase is the most commonly used, it can meet the needs of most chromatographic separations, but reversed-phase chromatography is difficult to separate highly polar compounds, because such polarity Compounds are extremely weakly retained on C8 / C18 stationary phases and tend to elute at dead times. In order to solve the problem of liquid phase separation of such strong polar compounds, hydrophilic interaction chromatography came into being [Document 1: D.García-Gómez, E.Rodríguez-Gonzalo, R.Carabias-Martínez, Trends Anal.Chem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/286B01J20/30B01D15/08
Inventor 肖红斌用天万伯顺
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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