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Application of total flavonoids from primula sikkmensis hook

A technology of bellflower primrose and total flavonoids, applied in the field of medicine, to achieve the effect of protecting ischemic myocardial cells, having a significant anti-myocardial ischemia effect, and treating acute myocardial ischemia

Inactive Publication Date: 2012-04-25
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report on the use of total flavonoids of Primula bellifera for the treatment of myocardial ischemia and the protection of ischemic myocardial cells

Method used

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  • Application of total flavonoids from primula sikkmensis hook
  • Application of total flavonoids from primula sikkmensis hook
  • Application of total flavonoids from primula sikkmensis hook

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 The preparation of the total flavonoids of Bellflower Primrose of the present invention

[0023] Take the dried coarse powder of bellflower and primrose, add 20 times the amount of 60% ethanol to soak, heat and reflux for extraction 3 times, each time for 1 hour, filter while hot, combine the filtrate, recover under reduced pressure until there is no alcohol smell, add appropriate amount of distilled water Finally, extract with n-butanol, recover the n-butanol solution under reduced pressure until there is no n-butanol smell, add an appropriate amount of distilled water to dissolve, and after filtration, the pretreated D101 macroporous adsorption resin on the filtrate is first eluted with distilled water until no Ferric chloride reaction and magnesium hydrochloride powder reaction occur, then elute with 30% ethanol, collect the eluent until no ferric chloride reaction and magnesium hydrochloride powder reaction occur, combine the eluent, recover the solvent,...

Embodiment 2

[0025] Example 2 Screening of the preparation method of total flavonoids from Primula bellflower

[0026] 1. Determination method of total flavonoids content

[0027] 1.1 Preparation of reference solution

[0028] Take rutin reference substance 0.01006g, place it in a 50ml volumetric flask, add 60% ethanol to make it up to the mark, and prepare a reference substance solution with a concentration of 0.2012mg / ml for future use.

[0029] 1.2 Preparation of sample solution

[0030] The extract prepared according to each preparation method is transferred to a 100ml volumetric flask, and the volume is fixed to the scale, and 10ml is precisely pipetted from the solution in the 100ml volumetric flask, and the sample solution is obtained by distilling to the volume with 60% ethanol. spare.

[0031] 1.3 Determination of measurement wavelength

[0032] Precisely pipette 7ml of the reference substance solution and 2ml of the test solution, place them in two 25ml volumetric flasks resp...

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Abstract

The invention discloses application of total flavonoids from primula sikkmensis hook to preparation of a medicament for treating myocardial ischemia. The invention also discloses a medicament composition for treating myocardial ischemia. The total flavonoids can reduce shift of the electrocardiogram ST segment and contents of serum LDH (lactic dehydrogenase) and CK (creatine kinase), can effectively prevent or / and treat acute myocardial ischemia and protect ischemic myocardial cells, have obvious effect on resisting myocardial ischemia and provide a new option for clinical medication.

Description

technical field [0001] The invention relates to a new application of total flavonoids of primrose bellflower, which belongs to the field of medicines. Background technique [0002] Myocardial ischemia refers to a pathological state in which the blood perfusion of the heart is reduced, resulting in reduced oxygen supply to the heart, abnormal myocardial energy metabolism, and failure to support the normal work of the heart. The common cause of myocardial ischemia is coronary atherosclerosis, followed by inflammation (rheumatism, syphilis, Kawasaki disease and vaso-occlusive vasculitis, etc.), spasm, embolism, connective tissue disease, trauma and congenital malformation, etc. Various. Studies have found that myocardial ischemia not only has the risk of myocardial infarction and sudden death, but more seriously, myocardial ischemia will cause damage to myocardial cells, such as myocardial cell edema, damage to the integrity of cell membranes and organelle membranes, etc. Eve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P9/10A61K133/00
Inventor 彭腾邓赟邱建平李鸿翔贺钢民
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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