Medicament for treating acute inflammation and preparation method thereof

An acute inflammation and drug technology, applied in the field of preparation of effective drugs, can solve the problems of reducing patient compliance, not dare to use the mechanism of action, and rapid onset

Inactive Publication Date: 2012-05-16
辽宁省中医药研究院
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of hormones does have many side effects, such as: obesity, acne, full moon face, osteoporosis, etc. If it is not used properly, it will easily lead to more serious lesions, etc.
Antibiotics are also commonly used drugs to treat acute inflammation, and are often used in combination with hormones, but the irrational use and abuse of antibiotics have also brought about more serious problems, such as serious flora imbalance or drug resistance , and even cause severe liver and kidney damage
Although new antibiotics with wider antibacterial spectrum and stronger anti-inflammatory effects have been continuously developed, the emergence and development of drug resistance cannot be controlled
Clinically, Chinese patent medicines and compound preparations are also used to treat acute inflammation. Although some Chinese medicines have been shown to have the effect of treating acute inflammation in the laboratory, there are still very few clinical applications. The main reason is that the foundation of previous research work is weak. , the active ingredients and targets of drugs are not clear, and acute inflammation is characterized by rapid onset and ferocious onset, so it is impossible and dare not for clinicians to use traditional Chinese medicine preparations with unclear mechanisms of action and ingredients for treatment; The traditional Chinese medicine preparations for acute inflammation are rough and have low therapeutic index, but in clinical practice it is necessary to take large doses to achieve the therapeutic purpose, which greatly reduces the compliance of patients

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicament for treating acute inflammation and preparation method thereof
  • Medicament for treating acute inflammation and preparation method thereof
  • Medicament for treating acute inflammation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Extract Group 1

[0021] Edelweiss medicinal material, add 7 times of water with a pH of 3.5 or 45% dilute ethanol, soak for 1 hour at 55°C, extract twice, filter, combine the filtrates, and recover the water or ethanol by rotary evaporation to contain 0.5% per 1ml The medicinal solution of g medicinal materials was left to stand for 48 hours to remove the precipitate, and the supernatant was placed on the macroporous adsorption resin column NKA-9, firstly eluted with 1 times the column volume of distilled water, followed by 3 times the column volume, and the volume fraction was Elute with 30% ethanol, collect the ethanol eluate, recover ethanol by rotary evaporation, and dry to dryness under reduced pressure. According to the amount of raw medicinal materials, the extracts are formulated into low, medium and high dose groups, respectively: low dose group 0.1g / ml, medium dose group 0.2g / ml, high dose group 0.4g / ml.

Embodiment 2

[0023] Extract Group 2

[0024] For edelweiss medicinal material, add 8 times of water with a pH of 4 or 50% dilute ethanol, soak for 1.5 hours at 60°C, extract 3 times, filter, combine the filtrates, and recover the water or ethanol by rotary evaporation to contain 0.5% per 1ml The medicinal solution of g medicinal materials, let it stand for 48 hours, remove the precipitate, put the supernatant on the macroporous adsorption resin column HPD500, first use 1.5 times the column volume to elute with distilled water, continue to use 4 times the column volume, the volume fraction is 40% The ethanol was eluted, the ethanol eluate was collected, the ethanol was recovered by rotary evaporation, and dried to dryness under reduced pressure. According to the amount of raw medicinal materials, the extracts are formulated into low, medium and high dose groups, respectively: low dose group 0.1g / ml, medium dose group 0.2g / ml, high dose group 0.4g / ml.

Embodiment 3

[0026] Extract Group 3

[0027] Edelweiss medicinal material, add 9 times of water with a pH of 4 or 60% dilute ethanol, soak for 2 hours at 60°C, extract 3 times, filter, combine the filtrates, and recover the water or ethanol by rotary evaporation to contain 0.5% per 1ml The medicinal solution of g medicinal materials was left to stand for 60 hours to remove the precipitate, and the supernatant was placed on the macroporous adsorption resin column X-5, and was first eluted with 2 times the volume of the column with distilled water, followed by 4 times the volume of the column, and the volume fraction was 45% ethanol was eluted, and the ethanol eluate was collected, and the ethanol was recovered by rotary evaporation, and dried to dryness under reduced pressure. According to the amount of raw medicinal materials, the extracts are formulated into low, medium and high dose groups, respectively: low dose group 0.1g / ml, medium dose group 0.2g / ml, high dose group 0.4g / ml.

[0028...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a medicament for treating acute inflammation, which is characterized in that the medicament is prepared by performing water extraction or alcohol extraction on an edelweiss medicament, loading on macroporous adsorbing resin column, eluting by using distilled water and ethanol and performing decompression and drying. The medicament is an effective medicament for resisting the acute inflammation, and an animal anti-inflammatory test for the medicament proves that the medicament has the obvious inhibiting effect on mouse auricle swelling caused by auricle; and the medicament has better effect than that of basic solution extracted directly by using water or dilute ethanol in the aspect of treating the acute inflammation.

Description

technical field [0001] The invention relates to a medicine for treating acute inflammation, and in particular provides a preparation method of an effective medicine for treating acute inflammation from edelweiss. Background technique [0002] Acute inflammation is the immediate and early response of the body to the stimulation of inflammatory factors. Acute inflammation has a sudden onset and is characterized by exudative lesions. The infiltration of inflammatory cells is mainly granulocytes, and the duration is short, only a few days to a month. If the acute inflammation is not controlled in time and treated correctly and thoroughly, it will spread and even turn into chronic inflammation, seriously endangering the body and other tissues and organs, and even life-threatening in severe cases. At present, hormone is an irreplaceable commonly used drug in the treatment of acute inflammation. If used properly and with appropriate coordination, its curative effect is definite, a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61P29/00
Inventor 姜鸿王光函刘轩刘晶邸子真杨明尤献民
Owner 辽宁省中医药研究院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap