Gene sequence related to rat spermatogenesis

Abstract

A gene sequence related to the rat spermatozoa pertains to the field of genetic engineering technology. The nucleotide sequence encoded by the gene related to the rat spermatogenesis, isolated or purified by the invention and its protein molecule sequence are provided, wherein, the nucleotide sequence is related to an DNA molecule of the isolated or purified nucleotide sequence having high homology with the rat gene, and the molecule has at least 70% homology with the nucleotide sequence from 459 to 1214 bit of the SEQ ID NO.3. The present invention relates to the gene that has important function for study of the molecular mechanism of spermatogenesis and simultaneously provides new information for understanding of male reproduction, the development of male contraceptives as well as how to improve male reproductive capacity in livestock breeding.

Description

technical field The present invention relates to a gene sequence in the technical field of genetic engineering, more specifically, relates to a gene sequence related to rat spermatogenesis. Background technique Spermatogenesis is a complex process, which includes: spermatogonial stem cells (spermatogonial stem cells, SSCs) undergo mitosis and meiosis, and then differentiate into A-type spermatogonia, B-type spermatogonia, primary spermatocytes, and secondary spermatocytes. Mother cells, sperm cells, and finally mature sperm. In this differentiation process, each specific stage is strictly regulated. Since each stage has cell-specific and developmental stage-specific structure formation, the transcription and expression of many stage-specific genes become the basis for the formation of stage-specific structures and specific cell functions of germ cells. Once any of these stages are mutated, it may affect the final sperm production. Today, nearly 15% of married couples in d...

AI Technical Summary

Problems solved by technology

But so far, people's research on the genes involved in spermatogenesis is still in its infancy. Although the effects of a few related genes have been studied, there are still a large number of unknown genes that have not been discovered.